Renal denervation and its role in the treatment of resistant hypertension

Authors: P. Vysočanová
Published in: Kardiol Rev Int Med 2012, 14(3): 207-210


Hypertension is a major health problem affecting approximately 35% of adult people. Some patients with hypertension are difficult to control despite the use of combinations of antihypertensive drugs and are considered as resistant to treatment. Hypertension is defined as resistant to treatment when a therapy of at least three drugs (including a diuretic) at correct doses has failed to control blood pressure to goal levels. The treatment of resistant hypertension includes life-style changes, the elimination of exogenous factors and secondary causes of hypertension, also the use of the maximum tolerated doses of combined antihypertensive drugs. Increasing understanding of the pathophysiology of hypertension may allow the development of new interventional method for the treatment of resistant hypertension. Renal denervation is a new invasive method of catheter based radiofrequency ablation of the sympathetic nerves located around renal arteries. The initial clinical experiences showed promising and long lasting decrease in blood pressures. Nevertheless renal denervation is still an experimental method to be used only in specialized research centers.

resistant hypertension – renal denervation – treatment


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Paediatric cardiology Internal medicine Cardiac surgery Cardiology
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